Cancerous breast tissue shows elevated bacteria levels, new research shows

Glen Mclaughlin
October 25, 2017

ONE in five women are at much higher risk of breast cancer because of faulty genes, new research shows. About half of the women that inherit either mutation will develop breast cancer by age 70.

Six months ago, something came up wrong in a mammogram for our own Stacy Lyn.

'There are some clear patterns in the genetic variants that should help us understand why some women are predisposed to breast cancer, and which genes and mechanisms are involved'.

Pinpointing specific genes is hard, but the OncoArray scientists were able to make predictions about many target genes - a first step towards designing new treatments.

In 2017, it is estimated that 17,586 women and 144 men will be diagnosed with breast cancer, according to Breast Cancer Network Australia.

Increased level of physical activity in the form of regular exercise is associated with a decreased risk for breast cancer, and this has been validated by numerous studies.

By combining epidemiological data with other data from breast tissue, the researchers were able to make plausible predictions of the target genes in the large majority of cases.

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"We know that breast cancer is caused by complex interactions between these genetic variants and our environment, but these newly discovered markers bring the number of known variants associated with breast cancer to around 180".

However, not all cancer cells carry this receptor - these are known as oestrogen-receptor negative. My passion for fund raising for the Breast Care Unit increases as I hear of more and more women who, like me, have benefitted from the care and support they received from the fantastic team at The Breast Care Unit whilst going through their breast cancer journey.

"We knew about 100 before, it is a big contribution but probably more important than the number is the methods we developed", she said.

They estimate that 1 per cent of women have a risk of breast cancer more than three times greater than that of women in the general population.

"These findings add significantly to our understanding of the inherited basis of breast cancer as well as identifying new genetic variants, we have also confirmed many that we had previously suspected", study investigator Doug Easton of the University of Cambridge said.

"Some of the variations are protective, others increase the risk". Just as it was true in 1985, it remains true today that mammography is the very best tool we have in the fight against breast cancer.

A further seven genes were identified specifically in association with breast cancers that lacked oestrogen receptors, which don't tend to respond to hormone based therapies.

Other reports by MaliBehiribAe

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