Ibuprofen male infertility issue joins cardiac risk as painkiller concerns grow

Glen Mclaughlin
January 10, 2018

The study, published this week in the journal Proceedings of the National Academy of Sciences (PNAS), monitored 31 healthy white men aged 18 to 35. A new study says the well-known painkiller could cause fertility issues in males. Ibuprofen has been shown to damage male fertility in athletes who regularly take the meds to manage pain, reported CNN.

The Danish research team warned: "Ibuprofen appears to be the preferred pharmaceutical analgesic for long-term chronic pain and arthritis". It was a randomized control trial, with one group of participants receiving ibuprofen and the others receiving placebo.

According to scientists, these men may also experience erectile dysfunction, fatigue, and muscle wastage, as prolonged ibuprofen usage disrupted testosterone hormones. This condition is linked to a reduction in fertility.

This led, they said, to compensated hypogonadism, a condition linked to reproductive and other health problems normally found in elderly men.

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On its own, a study this small would be little more than a call to do more detailed studies. This would lead to continuously low levels of testosterone, because the body could no longer compensate for the fall.

The condition, known as testosterone deficiency, is a failure of the testes to produce the male sex hormone testosterone, sperm or both. That works out to three ibuprofen tablets per day if you're taking a typical 200mg/tablet product. In 2017, the NSAID that goes by brand names including Motrin and Advil raises the risk of heart attacks. (In culture, there are no cells to produce luteinizing hormone to compensate.) The researchers found that a number of genes involved in steroid synthesis were affected by ibuprofen. Some took 1,200 milligrams of ibuprofen daily, which is the maximum limit as directed, over a six-week period.

"The safety and efficacy of active ingredients in these products has been well documented and supported by decades of scientific study and real-world use", said Mike Tringale, a spokesman for the association, according to Fox News. The effect was apparent at two weeks and became more pronounced after six weeks of ibuprofen use.

"These are the first-ever results to show a link between ibuprofen and fertility", Bernard Jegou, a senior scientist at the French Medical Research Council and the school of public health at the Research Institute for Environmental and Occupational Health in France, who coordinated the study, told The Telegraph.

Other reports by MaliBehiribAe

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